Additional information John Charles Hyptis Verticillata Commonly referred to as John Charles, Hyptis Verticillata is a pretty essential medicinal plants that has been used for generations for its great health benefits. Originally from Central America the Hyptis Verticillata has been used both in the traditional and modern setting for its great variety of medicinal properties and health benefits. Ever since people started using the plant for its medicinal purposes, it has spread beyond its native origin to parts of Florida, Columbia and across the Caribbean. The plant has got quite the history with records dating it way back to the ancient Aztec and Mayan Mesoamerican cultures. So far, there are neither indications nor proof that the plant was used beyond the Americas. Belonging to the order Laminales, Genus Hyptis and Family Lamiaceae, the Hyptis Verticillata is a plant that grows to an approximate height of 2 meters above the ground.

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Poit Rosangela A. Falcao,1 Patricia L. Moreira,2 Celso A. Camara,1 and Tania M. The leaves and bark are used in an infusion for the treatment of throat and skin inflammations, bacterial infections, pain, and cancer. Analogues of rosmarinic acid and flavonoids were obtained from the leaves of Hyptis pectinata and consisted of two new compounds, sambacaitaric acid 1 and 3-O-methyl-sambacaitaric acid 2 , and nine known compounds, rosmarinic acid 3 , 3-O-methyl-rosmarinic acid 4 , ethyl caffeate 5 , nepetoidin A 6 , nepetoidin B 7 , cirsiliol 8 , circimaritin 9 , 7-O-methylluteolin 10 , and genkwanin The structures of these compounds were determined by spectroscopic methods.

Compounds 1—5, and 7 were evaluated in vitro against the promastigote form of L. The hexane, ethyl acetate, and methanol-water fractions were also evaluated. In contrast, compounds 3, 5, and 7 did not present activity against the promastigote form of L. To our knowledge, compounds 1 and 2 are being described for the first time.

Introduction The Lamiaceae family is cosmopolitan and comprises genera and species [ 1 ]. This group is well known for its essential oils [ 2 ], which are rich in terpenoids, especially the subfamily Nepetoideae. In South America, Hyptis is one of the main genera of this subfamily and comprises species.

Of these species, are endemic to Brazil [ 3 ]. Hyptis pectinata L. Although there are some reports on the constituents of H. The leaves and bark are used in an infusion for the treatment of throat and skin inflammations, bacterial infections, pain and cancer [ 11 — 13 ].

The healing effect of H. Leishmaniasis is a major global public health problem, with three million cases annually [ 14 ]. American tegumentary leishmaniasis ATL is a serious zoonosis and is endemic throughout considerable areas of Latin America [ 15 ].

The main clinical forms of ATL are cutaneous leishmaniasis, mucosal or mucocutaneous leishmaniasis, and diffuse cutaneous leishmaniasis. In Brazil, ATL is found in all states and has shown a high incidence over the last 20 years; furthermore, the genetic diversity among Leishmania parasites is great.

At least seven Brazilian Leishmania species have been described as the etiological agent of human cutaneous disease, with most cases being caused by Leishmania Viannia braziliensis [ 16 — 18 ]. The drugs that are commercially used for the treatment of Leishmaniasis are highly toxic and require hospital monitoring because they may lead to death [ 19 ]. In this context, research on natural products for the treatment of leishmaniasis has been encouraged by the World Health Organization WHO through the Tropical Diseases Program [ 20 ].

The current work led to the isolation of two new compounds, namely sambacaitaric acid 1 and 3-O-methyl-sambacaitaric acid 2 Figure 1 , and nine known compounds from H. Figure 2 Chemical structures of compounds 2—7 isolated from H. Figure 3 Chemical structures of compounds 8—11 isolated from H. Materials and Methods 2. Sephadex LH Sigma was employed for gel permeation chromatography. All solvents used are of commercial HPLC grade. A portion of the EtOAc fraction 3.

Compounds 1 The purity of the compounds was examined via analytical HPLC with diode array detection. The cytotoxicities of the extract, fractions, and compounds against the promastigotes were determined. Stationary phase L. Each compound solution was added at increasing concentrations 0. Cells were also cultured in a medium without compounds and vehicle basal growth control or with DMSO 0. After 48 h, the extracellular load of L. Results and Discussion Upon extraction and fractionation, the leaves of Hyptis pectinata yielded compounds 1—11 Figures 1 — 3.

Compounds 1 and 2 were identified as new compounds and as rosmarinic acid analogues, based on the detailed NMR analysis described below Table 1.


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Mol Neurobiol. Epub Feb We evaluated if a nanostructured thermoreversible Pluronic Fbased hydrogel incorporated with Hyptis pectinata leaf essential oil NE-EOH produces a long-lasting anti-hyperalgesic effect on chronic muscle pain in an animal model. We induced chronic muscle pain by injecting the gastrocnemius with saline injections. Paw and muscle withdrawal thresholds and motor performance were evaluated after treatment and compared with morphine, diazepam, or vehicle. Naloxone and methysergide administration tested the involvement of opioid and serotonin receptors, respectively. NE-EOH increased paw and muscle withdrawal thresholds when compared with vehicle but had no effect on motor function.


John Charles (Hyptis Verticillata)

Hyptis pectinata Introduction Plants are a very important component of the ecosystem and without them we would not have the good balance we have in nature. There are several reasons why human beings and even animals would not do without plants. One of the benefits we derive from plants is their medicinal properties. For a long time people from diverse localities and backgrounds have depended on different plants for medicine. The hyptis pectinata is a good example of a plant that exhibits a lot of medicinal properties. Description The hyptis pectinata, commonly known as the bushmint is an aromatic flowering plant from the family of Lamiaceae.


Hyptis Pectinata – Woman Piaba

Kizilkree One alternative approach to increase the content of bioactive compounds is fermentation. Efficacy protection from H. At least one member shall represent a labor organization or employee group. Our study demonstrated for the first time antimicrobial activity of Hyptis atrorubens with identification of the active compounds. Research on the toxicity of Hyptis pectinata needs to be done to protect people from the possibility of its harmful effects.

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