Epub Feb Arjunolic acid: a new multifunctional therapeutic promise of alternative medicine. Ghosh J 1 , Sil PC. Indeed, tremendous demand for the development and implementation of these plant derived biomolecules in complementary and alternative medicine is increasing and appear to be promising candidates for pharmaceutical industrial research.
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We recommend that you prepare and use the solution on the same day. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial. Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
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Source of Arjunolic acid This product is isolated and purified from the fruits of Terminalia chebula Retz. Biological Activity of Arjunolic acid Description Arjunolic acid has antioxidant, anti-inflammatory, antinociceptive and anticholinesterasic AChE and BuChE activities, it may as promising targets for the development of innovative multi-functional medicines for Alzheimer desease treatment.
Arjunolic acid protects cardiac tissues from both extrinsic and intrinsic cell death pathways. Arjunolic acid exhibits better protection against histamine release than against acetylcholine release, anti-asthmatic and anaphylactic activity of it may be possibly due to membrane stabilizing potential and inhibition of antigen induced histamine and acetylcholine release.
Arjunolic acid protects cardiac tissues from both extrinsic and intrinsic cell death pathways, it also has antitumor activity. In recent years, a number of studies describing the effective therapeutic strategies of medicinal plants and their active constituents in traditional medicine have been reported.
Indeed, tremendous demand for the development and implementation of these plant derived biomolecules in complementary and alternative medicine is increasing and appear to be promising candidates for pharmaceutical industrial research.
These new molecules, especially those from natural resources, are considered as potential therapeutic targets, because they are derived from commonly consumed foodstuff and are considered to be safe for humans. Studies on the biochemistry and pharmacology suggest the potential use of Arjunolic acid as a novel promising therapeutic strategy.
The scientific basis behind its therapeutic application as a cardioprotective agent in traditional medicine is justified by its ability to prevent myocardial necrosis and apoptosis, platelet aggregation, coagulation and lowering of blood pressure, heart rate, as well as cholesterol levels. Its antioxidant property coupled with metal chelating property by its two hydroxyl groups protects different organs from metal and drug-induced organ pathophysiology.
Arjunolic acid also plays a beneficial role in the pathogenesis of diabetes and its associated complications. The mechanism of cytoprotection of Arjunolic acid, at least in part, results from the detoxification of reactive oxygen species ROS produced in the respective pathophysiology. In addition to its other biological functions, it also possesses vibrant insecticidal properties and it has the potential to be used as a structural molecular framework for the design of molecular receptors in the general area of supramolecular chemistry and nanochemistry.
Esters of Arjunolic acid function as organogelators which has wide application in designing thermochromic switches and sensor devices. Arjunolic acid derived crown ether is an attractive candidate for the design of molecular receptors, biomimetics and supramolecular systems capable of performing some biological functions.
This review also aims to untie the multifunctional therapeutic application of Arjunolic acid, a nanometer-long naturally occurring chiral triterpenoid biomolecule. EAC was induced in fifty female Swiss albino mice. Arjunulic acid reduced tumor volume and cells count. AA decreased EAC cells viability and increased cell toxicity.
Antiallergic and anti-asthmatic activities of the alcoholic extract of Terminalia arjuna and arjunolic acid.
In the present study, the alcoholic extract of Terminalia arjuna TA and Arjunolic acid AA were studied for its anti-asthmatic and anaphylactic activity. TA and AA also protected the guinea pig against histamine as well as acetylcholine induced bronchospasm.
In vivo Protective effects of arjunolic acid against cardiac toxicity induced by oral sodium nitrite: effects on cytokine balance and apoptosis. Sodium nitrite, a preservative used in meat products, helps in the production of free radicals, leading to increased lipid peroxidation, which plays a vital role in posing toxic effects in different body organs. On the other hand, Arjunolic acid possesses antioxidant properties and plays protective roles against chemically induced organ pathophysiology.
We investigated the effect of sodium nitrite on cardiac tissue in rats on the inflammatory cytokine balance and the type of induced apoptosis, and we analyzed the protective role of Arjunolic acid.
Cardiac mitochondrial activity cytochrome-C-oxidase , JNK activation and apoptosis caspase-3, caspase-8 and caspase-9 were assessed. Arjunolic acid markedly ameliorated these effects. Moreover, Arjunolic acid protected cardiac tissues from both extrinsic and intrinsic cell death pathways.
Cisplatin-induced testicular toxicity in rats: the protective effect of arjunolic acid. Lower tubular diameters and depletion of germ cells and irregular small seminiferous tubules with Sertoli cells only were observed in the cisplatin group. Arjunolic acid administration significantly corrected the changes in both biochemical and histopathological parameters. Protocol of Arjunolic acid Kinase Assay Arjunolic acid in the ethanolic extract of Combretum leprosum root and its use as a potential multi-functional phytomedicine and drug for neurodegenerative disorders: Anti-inflammatory and anticholinesterasic activities.
Its application is restricted now-a-days due to several acute and chronic side effects. ATO induced anti hypercholesterolemia and hepatic tissue toxicity has been reported to follow different mechanisms. Histological studies and DNA fragmentation analysis also support the toxic effect of ATO in these organs pathophysiology. Combretum leprosum Mart.
Cell Research Modes of action of arjunolic acid and derivatives on Trypanosoma cruzi cells. Chagas disease causes considerable morbimortality in the Americas, with circa 7 to 8 million infected people, causing at least 12, annual deaths and million people at risk. Its chemotherapy is poorly selective and effective, associated to severe side effects and unresponsive cases. Electron microscopy analysis revealed remarkable effects on the parasite surface and architecture.
AA-treated parasites displayed minutely corrugated plasma membranes devoid of subpellicular microtubules as well as biogenesis of multiple basal bodies. As the AA effects appeared mainly restricted or originated at the parasite peripheral cytoplasm, including the cytoskeleton membrane linkage, we inferred that the compound targeted primarily the lipid bilayer; therefore, we performed synthetic modification to increase the molecule lipophilicity and thus membrane permeability.
Parasites cultured with both derivatives displayed numerous and large autophagic vacuoles, altered flagellar length and cell body connection. CONCLUSIONS: These data indicate that synthetically-modified natural products comprise valuable tools in antiparasitic chemotherapy and that electron microscopy may be useful not only in determining the mechanisms of action but also in directing such modifications for rational drug design. Arjunolic acid Dilution Calculator.
Arjunolic acid: a new multifunctional therapeutic promise of alternative medicine.